By 
Erectile dysfunction (ED) is a very common disease, with an estimated 50% of Portuguese people having some degree of the disease. Its prevalence is dependent on age. The pathology affects 30% of men between 40-49 years old, 50% between 50-59 years old and 75% between 60-69 years old. Despite being a benign disease, it significantly changes the quality of life not only of the patient but of the couple. From the Tadalafil intermediate manufacturer factory the best solutions are available.
Erection Mechanism
Sexual stimulation, physical and / or mental, is responsible for an integrated response of the brain, nerves, blood vessels and hormones that leads to an increase in the blood supply to the penis and consequently to an erection.
Erectile Dysfunction is thus the manifestation of various diseases or treatments that can affect any of the actors involved in the erectile process. For the sake of simplicity we have divided the causes of erectile dysfunction into psychogenic or organic.
Psychogenic causes are, for example, due to marital stress or employment, performance anxiety, financial problems, depression, among others.
There are many situations that lead to erectile dysfunction of organic cause but the most frequent are: cardiovascular disease, hypertension, diabetes, high cholesterol, smoking, some neurological diseases such as Parkinson’s disease, multiple sclerosis or strokes, chronic alcoholism, some drugs used to treat hypertension, depression, antihistamines and illicit drugs or in the postoperative period of radical pelvic surgery to treat prostate cancer or colorectal cancer.
For an effective erectile mechanism it is necessary that the endothelium (the inner lining of blood vessels) is not altered.
Several epidemiological studies link the risk of ED with potentially modifiable cardiovascular risk factors such as hypertension, obesity, physical inactivity, smoking and elevated cholesterol. Normal endothelial functioning is altered by systematic aggression by these risk factors. As the cavernous arteries of the penis are the smallest caliber, they are the most affected early, thus alerting us to a more generalized arterial disease.
It is now known that erectile dysfunction can precede by 3-5 years a major cardiovalcular event such as stroke or acute myocardial infarction (AMI). ED thus acts as an alarm signal for arterial disease, which requires a more thorough vascular study of the patient.
Before starting specific treatment, a lifestyle change process should be started, such as the cessation of tobacco and alcohol, the adoption of a healthy diet and a regular exercise program. These measures not only improve health globally, but it is also verified that only with these changes 30% of patients improve their erectile dysfunction.
Although it can be treated effectively, ED, with some exceptions, has no cure.
We can divide ED treatment into 3 phases
In the first line of treatment, oral drugs are used: Sildenafil (Viagra), Vardenafil (Levitra) and Tadalafil (it comes from the Tadalafil manufacturer factory). Although they are different molecules, their mode of action is similar. They exert their action by relaxing smooth muscle within the corpora cavernosa which allows the penis to fill with blood; they do, however, need a concomitant sexual stimulus to cause an erection.
They have no effect on sexual desire or orgasm. They are very safe and highly effective (80% effectiveness rate), with a low adverse effect rate. Contrary to common sense, even patients with a history of AMI can use them, as long as prescribed by their urologist.
Comments